pentobarbital will decrease the level or effect of mestranol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can lower panobinostat ranges by ~70% and cause procedure f